Thursday, July 31, 2008

Cut your chance of getting cancer 10 to 1....

Today's post: Thursday, 7-31-2008


“The incidence of the top four cancers in the U.S. - colon, breast, prostate, and lung - is ten times lower in India.”

Research has now been done to explain why. There is evidence that taking one specific supplement can give you the same protection the people in India get.

(Note that this is on top of the many other actions, such as staying away from tobacco smoke, and getting the several other supplements and foods that protect you from getting cancer.

We’ve posted for example on taking boron, selenium, vitamin D, & resveratrol all of which, in addition to other health benefits, tend to prevent cancer. Eating raw broccoli & or cauliflower and other cruciferous vegetables, particularly if they are organically grown is also protective.)

People in India eat a lot of curried foods. Curries vary in their ingredients; but they all seem to contain the spice, turmeric, a member of the ginger family of spices. This produces a sharpness or heat to the food and imparts an intense yellow color.

A study published in the August 15, 2005 issue of the journal Cancer, found that curcumin, the active ingredient in turmeric, stopped laboratory strains of melanoma from proliferating and caused the cancer cells to commit suicide.

Since melanoma is one of the most dangerous and hard to kill cancers, I believe this is extremely significant news.

The research found that curcumin shut down nuclear factor-kappa B (NF-kB), a powerful protein that causes strong inflammatory responses that tend to cause cancer, arthritis, heart disease, and Alzheimer’s disease.

In fact, this effect may explain why curcumin seems to prevent Alzheimer’s disease as strongly as it prevents cancers.

Daily capsules of curcumin powder may also strongly slow growth of pancreatic cancer and multiple myeloma according to the authors of the study.

One of them also said that:: "The incidence of the top four cancers in the U.S. - colon, breast, prostate, and lung - is ten times lower in India,"

Curcumin made desirable changes in virtually every tumor biomarker they tested.

They found that curcumin down-regulates EGFR activity that mediates tumor cell proliferation, and the VEGF helps create in angiogenesis.

That means that curcumin tends to prevent cancers from growing and from getting increased access to blood supply. And, that means the cancer cells tend to stop growing and become starved for energy and oxygen.

They also found that curcumin reduces NF-kB and IKK the protein that turns NF-kB 0n& suppresses a STAT3 pathway that is also involved in tumorigenesis two. Both these pathways play a central role in cell survival and proliferation

One researcher said that curcumin’s ability to suppress numerous biological routes to cancer development is helped explain why it was effective. This helps to ensure “aptosis’ or death of the cancer cells.

They also found that. "The NF-kB machinery is suppressed by both short exposures to high concentrations of curcumin as well as by longer exposure to lower concentrations of curcumin,"

That suggests that if you take curcumin regularly as a supplement for quite some time, it will give you quite robust protection against getting cancer since with far less inflammation less cancers will start and any that develop will tend to die off instead of taking hold and growing.

It also suggests, that unlike some drugs and supplements where more is NOT better or is even dangerous -- such as taking more than 100 mg a day of vitamin B6 or far more than 10,000 iu of the retinol form of vitamin A-- if you have cancer, taking very large doses of curcumin may prove to be an effective treatment. The researchers found the desirable effects for both ways of taking the curcumin.

On a personal note, I’ve taken one capsule a day of curcumin for quite awhile for its ability to prevent Alzheimer’s disease.

The news that it also may have that strong of a preventive effect on prostate cancer for which I have a family history, AND colon and lung cancer is very welcome news.

I also am pleased that it looks likely to prevent breast cancer. And, it looks likely to prevent or even be a decent supplementary treatment for many other cancers.

I also forwarded the information on this study to my nephew who didn’t have a nasty looking mole on his leg checked out early and who is now being treated for stage III melanoma as a result.

It sounds like he would do well to take 3 capsules 3 times a day of curcumin for a month and then 3 a day after that. I read a report of the study instead of the study itself. If you can get a copy of the study, the study may show what amount of curcumin the authors tested as a “very large” dose and for how long they gave it to get the effects they found.

By the way, people who often eat curried food also get plenty of curcumin. If you have access to such foods several times a week and enjoy them, that may also work as the very low rate of these cancers in India suggests.

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